Hypothalamic and amygdalar cell lines differ markedly in mitochondrial rather than nuclear encoded gene expression
نویسندگان
چکیده
منابع مشابه
Neuroendocrine Gene Regulation in Hypothalamic Cell Lines
The physiological system implicated in the maintenance of energy homeostasis is situated predominantly in the hypothalamus. However, due to the inherent difficulty of studying individual neurons in the brain through in vivo analysis, cell models have been generated to investigate the direct action of hormones or other physiological compounds on metabolic effectors, such as neuropeptides, locate...
متن کاملEffect of curcumin and sorafenib on AKT gene expression in KG1 and U937 cell lines
Abstract Background and Objectives Acute myeloid leukemia is a heterozygous hematologic malignancy that is manifested by the accumulation of hematopoietics stem cells in peripheral blood and bone marrow. Anticancer effects and cryotoxic activity of curcumin have been proven frequently in many cancers. Sorafenib is known as an inhibitor of angiogenesis which prevent cells’ survival. In the...
متن کاملCLONING AND EXPRESSION OF LEISHMANOLYSIN GENE FROM LEISHMANIA MAJOR IN PRIMATE CELL LINES
Leishmanolysin is a worldwide disease that is caused by different species of the genus Leishmania. Leishmanolysin, One of the genes expressed by Leishmania, appears to be an ideal candidate for genetic vaccination. In this study, a full length sequence, which encodes Leishmanolysin functionally critical regions (amino acids 100-579), was cloned from a Leishmania strain endemic to Iran. Analysis...
متن کاملTranscription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.
Developmental transcription factors important in early neuron specification and differentiation often remain expressed in the adult brain. However, how these transcription factors function to mantain appropriate neuronal identities in adult neurons and how transcription factor dysregulation may contribute to disease remain largely unknown. The transcription factor Nurr1 has been associated with...
متن کاملInsulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ
Insulin sensitizing thiazolidinediones (TZDs) are generally considered to work as agonists for the nuclear receptor peroxisome proliferative activated receptor-gamma (PPAR gamma). However, TZDs also have acute, non-genomic metabolic effects and it is unclear which actions are responsible for the beneficial pharmacology of these compounds. We have taken advantage of an analog, based on the metab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Genomics
سال: 2013
ISSN: 1471-2164
DOI: 10.1186/1471-2164-14-413